David Sinclair, PhD


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Everything we think we know about ageing is about to change

Across the globe, scientists are working on treatments and therapies that are designed to extend healthy human lifespans well beyond what we know today. Will you help educate the world about this coming revolution?

 What Happens To Our Cells When We Age?

As cells age, they become larger and less capable of reproduction, undergoing changes that eventually result in the loss of cellular identity. For years, scientists have argued about why these changes occur, but popular opinion has coalesced around nine “hallmarks of aging.” But are these hallmarks a cause or a symptom?

In his new book, Lifespan, David Sinclair has proposed a radical new theory of aging, suggesting that the aging hallmarks are symptoms of epigenetic changes that occur over time, but that the original genetic code remains very much intact.

If we can reset the code, can we slow, stop or even reverse aging? Sinclair believes we can. 


About the Author

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political risks and benefits of a world in which billions of people can live much longer and much healthier lives.

Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. (A full list of disclosures is available here.)

He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time's Top 50 in healthcare in 2018.

A Quick KeaLad Commentary on Lifespan

Full disclosure, this is one read that's still on my to-do list (high priority!). That said, the premise is very promising and David Sinclair has certainly been involved with some very interesting new research! So personally I can't wait - and I will update this section after I've given it a good study. :)

Your KeaLad, Thomas - VitaKea Caretaker 🌿       

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